Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetJNK

Cell permeable: yes

General description

The non-permeant JNK inhibitor peptide TI-JIP_153-163 (Cat. No. 420133) is made cell-permeable with an N-terminal TAT protein transduction domain sequence. Shown to offer neuroprotection in a rat ischemic brain injury model in in vivo.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Guan, Q.H., et al. 2006. Neuroscience, 139, 609.Barr, R.K., et al. 2004. J. Biol. Chem.279, 36327.Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett.8, 550.Barr, R.K., et al. 2002. J. Biol. Chem.277, 10987.

Packaging

2 mg in Plastic ampoule

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sequence

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂

Warning

Toxicity: Standard Handling (A)